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Long-term Outcome of DSM-IV Major Depressive Disorder in Psychiatric Care
Mikael Holma
Nidottu. Terveyden ja hyvinvoinnin laitos THL 2010.
ISBN 9789522453693
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Kustantamon esittely
The prevailing view of outcome of major depressive disorder (MDD) is based on mostly inpatient tertiary centre cohorts, and emphasizes chronicity and frequent recurrences. This study investigated the 5-year outcome of MDD among psychiatric out- and inpatients as a part of the Vantaa Depression Study (VDS), a regionally representative, prospective and naturalistic follow-up study. The long-term outcome of MDD was in these settings more variable than in earlier, mostly inpatient studies, while MDD was still highly recurrent, but the recurrent episodes seemed shorter, and the outcome was less chronic. Higher severity of MDD, episode duration and preceding dysthymia, comorbid cluster C personality disorders and social phobia predicted a worse outcome. Time spent depressed was the central factor determining overall long-term risk of suicide attempts together with a history of attempts and poor social support. A switch to bipolar disorder occurred mainly to type II, and was predicted by higher severity of MDD, and comorbid disorders. Having a positive family history of severe mental disorders was likely to be clinically associated with a significantly more adverse outcome
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Long-term Outcome of DSM-IV Major Depressive Disorder in Psychiatric Care
Kirja-arvostelut » Long-term Outcome of DSM-IV Major Depressive Disorder in Psychiatric Care
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